Pianissimo family (IPR028268)

Short name: Pianissimo_fam

Overlapping homologous superfamilies


Family relationships



Protein pianissimo (PiaA) is a component of the target of rapamycin complex 2 (TORC2) in Dictyostelium [PMID: 16079174]. This complex regulates cell growth, chemotaxis, signal relay and the actin cytoskeleton. Homologues of PiaA are found in Saccharomyces cerevisiae (TSC11/AVO3) [PMID: 15809876], Schizosaccaromyces pombe (Ste20) [PMID: 17261596], and vertebrates, where it is also known as Rictor (rapamycin-insensitive companion of mTOR) [PMID: 16962829, PMID: 15268862].

Rictor, together with Sin1, is believed to function as an adaptor protein controlling the mTORC2 substrate binding and specificity. Rictor is known to have a role in cytoskeleton regulation and cell migration [PMID: 15268862, PMID: 22777355]. It is likely that rictor regulates cell morphology and migration by playing a role as the indispensable component of mTORC2 and also by carrying mTORC2-independent functions.

GO terms

Biological Process

GO:0031929 TOR signaling

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0031932 TORC2 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.