M-phase-specific PLK1-interacting protein-like (IPR028265)

Short name: MPLKIP-like

Family relationships


This entry represents M-phase-specific PLK1-interacting protein and related uncharacterised sequences from animals and plants.

M-phase-specific PLK1-interacting protein (also known as TTD non-photosensitive 1 protein, TTDN1) co-localises with Plk1 at the centrosome in mitosis and the midbody during cytokinesis [PMID: 17310276]. TTDN1 is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1 (PLK1) [PMID: 17310276, PMID: 15645389]. It may play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis [PMID: 17310276].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.