TTDN1/Protein SICKLE (IPR028265)

Short name: TTDN1/SICKLE

Overlapping homologous superfamilies


Family relationships


This entry includes animal M-phase-specific PLK1-interacting protein (also known as TTDN1) and plant protein SICKLE.

M-phase-specific PLK1-interacting protein (also known as TTD non-photosensitive 1 protein, TTDN1) co-localises with Plk1 at the centrosome in mitosis and the midbody during cytokinesis [PMID: 17310276]. TTDN1 is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1 (PLK1) [PMID: 17310276, PMID: 15645389]. It may play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis [PMID: 17310276]. Mutations in the C7orf11 (TTDN1) gene has been linked to Trichothiodystrophy (TTD), a rare autosomal recessive disorder whose defining feature is brittle hair [PMID: 16977596].

Protein SICKLE is required for development and abiotic stress tolerance, and is involved in microRNA biogenesis [PMID: 23071326] and mRNA splicing [PMID: 27624757]. SICKLE, also known as ROTUNDA 3, may contribute to plant development by phosphatase 2A-mediated regulation of auxin transporter recycling [PMID: 26888284].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.