Exocyst complex component Sec3, PIP2-binding N-terminal domain (IPR028258)

Short name: Sec3-PIP2_bind

Overlapping homologous superfamilies


Domain relationships



This is the N-terminal domain of fungal and eukaryotic Sec3 proteins. Sec3 is a component of the exocyst complex that is involved in the targeting and tethering of post-Golgi secretory vesicles to fusion sites on the plasma membrane prior to SNARE-mediated fusion. This N-terminal domain contains a cryptic pleckstrin homology (PH) fold, and all six positively charged lysine and arginine residues in the PH domain predicted to bind the phosphatidylinositol 4,5-bisphosphate (PIP2) head group are conserved. In fission yeast, polarised exocytosis for growth relies on the combined action of the exocyst at cell poles and myosin-driven transport along actin cables [PMID: 22768263].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.