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Overview
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Pathways & interactions
Domain
Thiol:disulfide interchange protein DsbD, N-terminal domain (IPR028250)
Short name: DsbDN
Overlapping homologous superfamilies
Domain relationships
None.
Description
Folding of secreted proteins within the periplasm of Escherichia coli requires the formation of disulfide bonds, a process that is dependent on the Dsb (disulfide bond) proteins. The reduction of Dsb proteins DsbC, DsbE, and DsbG occurs by transport of electrons from cytoplasmic thioredoxin to the C-terminal thioredoxin-like domain of DsbD (DsbDC). The N-terminal domain of DsbD (DsbDN) is capable of forming disulfides with oxidized DsbC, DsbE, or DsbG as well as with reduced DsbD [PMID: 12033924]. This entry represents DsbDN.
Contributing signatures
Signatures from InterPro member databases are used to construct an entry.
Pfam
- PF11412 (DsbC)