AP-5 complex subunit zeta-1 (IPR028222)

Short name: AP5Z1

Overlapping homologous superfamilies


Family relationships



AP-5 complex subunit zeta-1 is a component of the fifth Adaptor-Protein complex (AP-5) [PMID: 22022232]. Adaptor protein (AP) complexes facilitate the trafficking of cargo from one membrane compartment of the cell to another by recruiting other proteins to particular types of vesicles. AP-5 is involved in trafficking proteins from endosomes towards other membranous compartments [PMID: 22022230]. There are genetic links between AP-5 and hereditary spastic paraplegia, a group of human genetic disorders characterised by progressive spasticity in the lower limbs [PMID: 20613862].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0044599 AP-5 adaptor complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.