Family

SLP adapter and CSK-interacting membrane protein (IPR028181)

Short name: SCIMP

Family relationships

None.

Description

SLP adapter and CSK-interacting membrane protein (SCIMP) is a lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex class II (MHC-II) signaling transduction [PMID: 21930792]. SCIMP is expressed in B cells and other professional antigen-presenting cells (APCs) and is localised in the immunological synapse. Upon MHC-II stimulation, phosphorylated SCIMP binds to the SLP65 and to the inhibitory kinase Csk. SLP65 binding initiates the downstream signaling cascades, while Csk binding functions as a negative regulatory loop [PMID: 21930792].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0001772 immunological synapse
GO:0016021 integral component of membrane
GO:0097197 tetraspanin-enriched microdomain

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
Pfam