Interleukin-21 (IPR028151)

Short name: IL-21

Overlapping homologous superfamilies

Family relationships


Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells.

This entry represents interleukin-21, which is found in mammals and birds. IL-21, in synergy with IL-15, is thought to play a role in proliferation and maturation of natural killer (NK) cells. It may also regulate proliferation of mature B- and T-cells in response to activating stimuli [PMID: 15100251, PMID: 17312126, PMID: 17884812]. Along with IL-15 and IL18, IL-21 stimulates interferon gamma production in T-cells and NK cells [PMID: 12759422]. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation [PMID: 11081504, PMID: 15178704].

GO terms

Biological Process

GO:0006955 immune response

Molecular Function

GO:0005126 cytokine receptor binding

Cellular Component

GO:0005615 extracellular space

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.