Humanin family (IPR028139)

Short name: Humanin

Family relationships



Humanin (HN) and humanin-like proteins are found exclusively in humans. Humanin is a short anti-apoptotic peptide that inhibits the activation of Bax (Bcl-2-associated X protein), which is involved in apoptosis [PMID: 12732850]. Humanin suppresses neuronal cell death caused by Alzheimer's disease (AD)-specific insults [PMID: 12009529]. Humanin also interacts with the insulin-like growth factor-binding protein-3 (IGFBP-3), which is essential in the regulation of cell survival [PMID: 14561895]. This entry represents the humanin family, and also matches some uncharacterised non-human proteins, mainly from chimpanzee.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.