Ubiquitin carboxyl-terminal hydrolase USP4 (IPR028134)

Short name: USP4

Overlapping homologous superfamilies

Family relationships



Ubiquitin-specific proteases (USPs) are a family of hydrolases that specifically remove polypeptides covalently linked to the C-terminal glycine of ubiquitin. They are important regulators of ubiquitin mediated protein degradation and signaling, thereby influencing major cellular events such as cell cycle progression, transcriptional regulation, and DNA damage repair [PMID: 21848306].

USP4 is characterised by the presence of N-terminal DUSP and UBL domains (DU subfamily) [PMID: 22001210]. USP4 plays a role in the regulation of quality control in the endoplasmic reticulum [PMID: 16339847].

GO terms

Biological Process

GO:0016579 protein deubiquitination

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.