Dynamitin (IPR028133)

Short name: Dynamitin

Overlapping homologous superfamilies


Family relationships



Dynactin is a multiprotein complex necessary for the function of microtubule motor protein dynein. The dynein-dynactin complex is involved in a variety of cellular events, including membrane vesicle transport, mitotic spindle assembly and centrosome separation [PMID: 19935668, PMID: 9522459, PMID: 10047518].

Dynamitin (dynactin subunit 2, DCTN2) is a subunit of the dynactin complex. In Saccharomyces cerevisiae it is also known as Jnm1. Dynactin contains two distinct structural domains: a projecting sidearm that interacts with dynein and an actin-like minifilament backbone that is thought to bind cargo. Dynamitin holds together both structural domains [PMID: 10525537]. Dynamitin is implicated in cell adhesion by binding to macrophage-enriched myristoylated alanine-rice C kinase substrate (MacMARCKS) [PMID: 12082093]. In mice, DCTN2 is involved in anchoring microtubules to centrosomes and may play a role in synapse formation during brain development [PMID: 9144527].

GO terms

Biological Process

GO:0007017 microtubule-based process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005869 dynactin complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.