Telomere repeats-binding bouquet formation protein 2 (IPR028065)

Short name: TERB2

Overlapping homologous superfamilies


Family relationships



Telomere repeats-binding bouquet formation protein 2 (TERB2) is a meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. It is a component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA [PMID: 26548954].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.