Domain

Kinetochore assembly subunit CENP-C, N-terminal domain (IPR028052)

Short name: CENP_C_N_dom

Domain relationships

None.

Description

CENP-C is a vertebrate family that forms a core component of the centromeric chromatin. On depletion of CENP-C, proper formation of both centromeres and kinetochores is prevented. In kinetochores, the KMN (KNL1/Mis12/Ndc80) network regulates kinetochore microtubule binding [PMID: 17129783]. The N-terminal of CENP-C is necessary for recruitment of some but not all components of the Mis12 complex to centromeres [PMID: 20702077, PMID: 21353555].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam