Domain

Katanin p80 subunit, C-terminal (IPR028021)

Short name: Katanin_C-terminal

Domain relationships

None.

Description

This entry represents the C-terminal domain of katanin 80 kDa subunit. Katanin is a microtubule-severing protein consist of a 60 kDa ATPase subunit (katanin-p60) and a 80 kDa subunit (katanin-p80) [PMID: 8221885]. Katanin-p80 is composed of an N-terminal WD40 repeat domain, a central proline-rich domain and a C-terminal domain required for dimerisation with the catalytic katanin-p60. The katanin complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of katanin-p60 to the spindle poles [PMID: 10751153]. It was suggested that katanin is targeted to spindle poles through a combination of direct microtubule binding by the katanin-p60 and through interactions between the WD40 domain and an unknown protein [PMID: 17846175].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam