Domain

Ephrin receptor, transmembrane domain (IPR027936)

Short name: Eph_TM

Domain relationships

None.

Description

This entry represents the left-handed dimer transmembrane domain of Ephrin receptors. This domain oligomerises and is important for the active signalling process [PMID: 20197042].

Proteins containing this domain include the ephrin type-A and type-B receptors. Ephrin receptors (Ephs) are a group of receptor tyrosine kinases that are activated in response to binding ephrin ligands residing on adjacent cells [PMID: 12094214]. This binding leads to contact-dependent bidirectional signaling into neighbouring cells [PMID: 12094214].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam