MCM N-terminal domain (IPR027925)

Short name: MCM_N

Overlapping homologous superfamilies

Domain relationships



This entry represents the N-terminal region of MCM proteins. This region is composed of three structural domains. Firstly a four helical bundle, secondly a zinc binding motif and thirdly an OB-like fold [PMID: 12548282].

MCM proteins are DNA-dependent ATPases required for the initiation of eukaryotic DNA replication [PMID: 1454522, PMID: 8265339, PMID: 14731643]. In eukaryotes there is a family of six proteins, MCM2 to MCM7. They were first identified in yeast where most of them have a direct role in the initiation of chromosomal DNA replication by interacting directly with autonomously replicating sequences (ARS). They were thus called minichromosome maintenance proteins, MCM proteins [PMID: 8332451].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.