Family

Proline-rich acidic protein 1 (IPR027922)

Short name: PRAP

Family relationships

None.

Description

PRAP, or proline-rich acidic protein 1, is a family of eukaryotic proteins. PRAP is abundantly expressed in the epithelial cells of the human liver, kidney, gastrointestinal tract, and cervix. It is significantly down-regulated in hepatocellular carcinoma and right colon adenocarcinoma compared with the respective adjacent normal tissues. It is expressed in the epithelial cells of the mouse and rat gastrointestinal tracts, and pregnant mouse uterus. In humans, PRAP is abundantly expressed in the epithelial cells of the liver, kidney, gastrointestinal tract, and cervix. PRAP plays an important role in maintaining normal growth suppression [PMID: 14583459].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam