Replication termination factor 2, RING-finger (IPR027799)

Short name: Rtf2_RING-finger

Overlapping homologous superfamilies


Domain relationships



It is vital for effective cell-replication that replication is not stalled at any point by, for instance, damaged bases. Replication termination factor 2 (Rtf2) stabilises the replication fork stalled at the site-specific replication barrier RTS1 by preventing replication restart until completion of DNA synthesis by a converging replication fork initiated at a flanking origin. The RTS1 element terminates replication forks that are moving in the cen2-distal direction while allowing forks moving in the cen2-proximal direction to pass through the region. Rtf2 contains a C2HC2 motif related to the C3HC4 RING-finger motif, and would appear to fold up, creating a RING finger-like structure but forming only one functional Zn2+ ion-binding site [PMID: 19416828]. This domain is also found at the N terminus of peptidyl-prolyl cis-trans isomerase 4, a divergent cyclophilin family [PMID: 9803414].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.