tRNase Z endonuclease (IPR027794)

Short name: tRNase_Z_dom

Overlapping homologous superfamilies

Domain relationships



This domain is found in the RNase Z enzymes, which are closely related structurally to the Lactamase B family members. tRNase Z (ribonuclease Z) is the endonuclease that is involved in tRNA 3'-end maturation through removal of the 3'-trailer sequences from tRNA precursors. The fission yeast Schizosaccharomyces pombe contains two candidate tRNase Zs encoded by two essential genes. The first, Trz1, is targeted to the nucleus and has an SV40 nuclear localisation signal at its N terminus, consisting of four consecutive arginine and lysine residues between residues 208 and 211 (KKRK) that is critical for the NLS function. The second, Trz2, is targeted to the mitochondria, with an N-terminal mitochondrial targeting signal within the first 38 residues [PMID: 21208191].

GO terms

Biological Process

GO:0008033 tRNA processing

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.