Family

Zinc finger protein PLAG1 (IPR027765)

Short name: PLAG1

Family relationships

Description

PLAG1 and PLAG1 family members PLAGL1 and PLAGL2 constitute a family of zinc finger proteins that recognise DNA and/or RNA. This entry represents PLAG1.

Zinc finger protein PLAG1, also known as pleiomorphic adenoma gene 1 protein, is a transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. PLAG1 is a proto-oncogene whose ectopic expression can trigger the development of tumours, including pleomorphic adenomas of the salivary gland and lipoblastomas [PMID: 15930271, PMID: 16108035, PMID: 17332914].

GO terms

Biological Process

GO:0006351 transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER