Zinc finger protein PLAG1 (IPR027765)

Short name: PLAG1

Overlapping homologous superfamilies


Family relationships



PLAG1 and PLAG1 family members PLAGL1 and PLAGL2 constitute a family of zinc finger proteins that recognise DNA and/or RNA. This entry represents PLAG1.

Zinc finger protein PLAG1, also known as pleiomorphic adenoma gene 1 protein, is a transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. PLAG1 is a proto-oncogene whose ectopic expression can trigger the development of tumours, including pleomorphic adenomas of the salivary gland and lipoblastomas [PMID: 15930271, PMID: 16108035, PMID: 17332914].

GO terms

Biological Process

GO:0006351 transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.