RE1-silencing transcription factor (IPR027757)

Short name: REST

Overlapping homologous superfamilies


Family relationships



The Repressor Element-1 (RE-1) Silencing Transcription (REST) factor is a transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells [PMID: 7697725, PMID: 12399542]. REST is involved in neural differentiation and in preservation of the neural phenotype. REST also plays a role in proliferation, although its effect differs depending on the cell type [PMID: 23414932].

GO terms

Biological Process

GO:0050768 negative regulation of neurogenesis
GO:0045665 negative regulation of neuron differentiation
GO:0043065 positive regulation of apoptotic process
GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.