EB2, vertebrate (IPR027735)

Short name: RP1/EB2_vertebrate

Overlapping homologous superfamilies


Family relationships


Microtubule-associated protein RP/EB family member 2 (also known as RP1 or EB2) belongs to the RP/EB family, which consists of MAPRE1 (EB1), MAPRE2 (RP1, also known as EB2) and MAPRE3 (EBF3, also known as EB3). Unlike EB1 and EB3, EB2 does not promote persistent microtubule growth by suppressing catastrophes [PMID: 19255245]. It has been shown that MAPRE2 is highly expressed in pancreatic cancer cells, and seems to be involved in perineural invasion [PMID: 19787265].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.