Heat shock transcription factor, Y-linked (IPR027730)

Short name: HSFY

Overlapping homologous superfamilies


Family relationships


HSFY and its homologous gene on the X chromosome, HSFX, show 53% homology for their DNA-binding domains, which are similar to HSF family members, but the other regions show low similarity. Both HSFY and HSFX are predominantly expressed in testes and have novel characteristics compared with other HSFs [PMID: 15044259].

In eukaryotes heat shock factors (HSFs) induce transcription of heat shock genes following stress and in response to developmental signals [PMID: 10440228]. HSFs recognise cis-acting promoter elements composed of variations of an inverted repeat called heat shock elements (HSE) [PMID: 20844575]. Both HSF and HSEs are conserved in their fundamental structures from yeast to humans.

In general, HSFs contain an N-terminal DNA-binding domain of the helix-turn-winged helix type, one or more coiled-coil trimerisation domains, nuclear localisation domains, and a C-terminal trans-activation domain [PMID: 11344080]. HSF is present in a latent state under normal conditions; it is activated upon heat stress by induction of trimerisation and high-affinity binding to DNA and by exposure of domains for transcriptional activity [PMID: 8689565].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.