Teneurin-2/3 (IPR027689)

Short name: Ten-2/3

Overlapping homologous superfamilies


Family relationships



Teneurin (also known as odd Oz, tenascin-m, neurestin, or DOC4) are large cell surface glycoproteins with a single transmembrane region. Their ectodomains contain eight EGF-like repeats, two of which have unpaired cysteine residues that mediate covalent homodimerisation of the molecule [PMID: 10225957]. The four teneurins expressed in vertebrates are predominately found in brain.

Teneurin-2 is involved in neural development, regulating the establishment of proper connectivity within the nervous system [PMID: 12361962]. Lasso, a splice variant of teneurin-2, acts as a ligand for latrophilin 1 (LPH1), a neuronal receptor of alpha-latrotoxin [PMID: 21724987]. LPH1 and Lasso can form transsynaptic complexes capable of inducing presynaptic Ca(2+) signals, which might affect synaptic functions [PMID: 21724987].

Teneurin-3 promotes axon guidance and homophilic cell adhesion. It plays a role in the development of the visual pathway and may function as a cellular signal transducer [PMID: 17803360, PMID: 17478416].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.