Teneurin-1/4 (IPR027688)

Short name: TENM1/TENM4

Overlapping homologous superfamilies


Family relationships



Teneurin (also known as odd Oz, tenascin-m, neurestin, or DOC4) are large cell surface glycoproteins with a single transmembrane region. Their ectodomains contain eight EGF-like repeats, two of which have unpaired cysteine residues that mediate covalent homodimerisation of the molecule [PMID: 10225957]. The four teneurins expressed in vertebrates are predominately found in brain.

Teneurin-1 and teneurin-4 are involved in neural development, regulating the establishment of proper connectivity within the nervous system. Teneurin-4 has a role in gastrulation in mice [PMID: 15489520] and may be involved in bipolar disorder in humans [PMID: 21926972]. In the central nervous system, it regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons [PMID: 22915103]. It promotes activation of focal adhesion kinase and may function as a cellular signal transducer [PMID: 22915103].

Teneurin-1 may function as a cellular signal transducer [PMID: 15777793]. It can be cleaved into 2 chains: Teneurin C-terminal-associated peptide and Ten-1 intracellular domain. Teneurin C-terminal-associated peptide plays a role in the regulation of neuroplasticity in the limbic system. It mediates a rapid reorganisation of actin and tubulin based cytoskeleton elements with an increase in dendritic arborisation and spine density formation of neurons in the hippocampus and amygdala [PMID: 15710242]. The Ten-1 intracellular domain induces gene transcription activation [PMID: 17900539].

GO terms

Biological Process

GO:0048666 neuron development

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.