I-BAR domain containing protein MTSS1 (IPR027682)

Short name: MTSS1

Overlapping homologous superfamilies


Family relationships


MTSS1(metastasis suppressor protein 1, also known as MIM) is an I-BAR (Bin/amphipysin/Rvs) domain containing protein. BAR domain forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. The BAR domain containing proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature [PMID: 21743456].

MIM also contains an additional C-terminal WH2 domain that binds G-actin. In mice MIM inhibits the nucleation of actin filaments in vitro [PMID: 12482861]. In humans MIM may be related to cancer progression or tumour metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton [PMID: 12570871]. MIM undergoes Src-dependent tyrosine phosphorylation, and this phosphorylation is important for actin remodelling [PMID: 21093245]. MIM is also involved in the sonic hedgehog (Shh) signalling [PMID: 20708589].

GO terms

Biological Process

GO:0030036 actin cytoskeleton organization

Molecular Function

GO:0003779 actin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.