Exostosin 3/Exostosin-like 3 (IPR027674)

Short name: EXO3/EXOL3

Family relationships


There are five identiied human EXT family proteins (EXT1, EXT2, EXTL1, EXTL2 and EXTL3), which are members of the hereditary multiple exostoses family of tumor suppressors [PMID: 17237233]. Exostosin-3 (EXT3) from Drosophila melanogaster and exostosin-like 3 (EXTL3) are N-acetylglucosamine transferases involved in heparan sulfate biosynthesis [PMID: 9479495, PMID: 11832488]. This entry also include Caenorhabditis elegans exostosin-2 (also known as rib-2). In Caenorhabditis elegans, only two proteins, EXT1 (rib-1) and EXT2 (rib-2), homologous to the mammalian EXT genes have been identified [PMID: 17237233].

GO terms

Biological Process

GO:0015012 heparan sulfate proteoglycan biosynthetic process

Molecular Function

GO:0008375 acetylglucosaminyltransferase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.