Family

Dynactin subunit 1 (IPR027663)

Short name: DCTN1

Family relationships

None.

Description

Dynactin subunit 1 (also known as p150Glued) is the largest subunit of the dynactin complex, which consists of 11 distinct components organised into three major structural domains. The complex includes the core Arp1 filament (Arp1,actin), actin-binding protein cap (CapZ alpha/beta), pointed end complex (Arp11, p62, p27, and p25) and the sidearm/shoulder structure (p150Glued, dynamitin, and p24) [PMID: 22918948].

Dynactin modulates binding of dynein to cell organelles which are to be transported along microtubules [PMID: 15473859]. Dynactin subunit 1 (p150Glued) co-localises with microtubules and is essential for dynactin function [PMID: 15473859, PMID: 17828277]. In humans, alternative splicing results in several distinct isoforms of dynactin subunit 1. Ssm4 is the fission yeast homologue of p150Glued [PMID: 15509865].

Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B. HMN7B is a neuromuscular disorder [PMID: 12627231]. Defects in DCTN1 is also a cause of susceptibility to amyotrophic lateral sclerosis (ALS) and the cause of Perry syndrome (PERRYS). ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis [PMID: 15326253]. Perry syndrome is a neuropsychiatric disorder characterised by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss [PMID: 19136952].

GO terms

Biological Process

GO:0010970 transport along microtubule

Molecular Function

GO:0070840 dynein complex binding

Cellular Component

GO:0005869 dynactin complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER