Pathways & interactions
Short name: SGCG
Overlapping homologous superfamilies
- Sarcoglycan complex subunit protein (IPR006875)
- Gamma-sarcoglycan (IPR027660)
Gamma-sarcoglycan (SGCG) is a component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix [PMID: 9864373]. Defects in SGCG are the cause of limb-girdle muscular dystrophy type 2C (LGMD2C). LGMD2C is characterised by progressive muscle wasting from early childhood [PMID: 7481775, PMID: 8900232, PMID: 8968757, PMID: 10714584].
- PTHR12939:SF4 (PTHR12939:SF4)