Formin, protein diaphanous homologue 3 (IPR027654)

Short name: Formin_DIAPH3

Overlapping homologous superfamilies


Family relationships



Protein diaphanous homologue 3 (DIAPH3) belongs to the formin homology family, Diaphanous subfamily (also known as the Diaphanous-related formins, Drfs). In addition to the FH1 and FH2 domains, Drfs contain an N-terminal GTPase-binding domain (mDiaN) and a C-terminal Diaphanous-autoregulatory domain (DAD).

DIAPH3 (also known as mDia2, which can be confusing) acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerisation. It is required for cytokinesis, stress fibre formation, and transcriptional activation of the serum response factor [PMID: 10678165]. It couples Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics [PMID: 10678165].

GO terms

Biological Process

GO:0030036 actin cytoskeleton organization

Molecular Function

GO:0017048 Rho GTPase binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.