Family

Disheveled-associated activator of morphogenesis 1 (IPR027650)

Short name: DAAM1

Family relationships

None.

Description

Disheveled-associated activator of morphogenesis 1 (Daam1) belongs to the formin homology family.

In humans, Daam1 binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. It may play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. It can also direct nucleation and elongation of new actin filaments [PMID: 16630611].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0017048 Rho GTPase binding
GO:0003779 actin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER