Protein diaphanous homologue 2 (IPR027644)

Short name: DIAPH2

Overlapping homologous superfamilies


Family relationships



DIAPH2 belongs to the formin homology family, Diaphanous subfamily (also known as the Diaphanous-related formins, Drfs). In addition to the FH1 and FH2 domains, Drfs contain an N-terminal GTPase-binding domain (mDiaN) and a C-terminal Diaphanous-autoregulatory domain (DAD).

DIAPH2 may be involved in oogenesis and in the regulation of endosome dynamics. In humans, DIAPH2 has three isoforms produced by alternative splicing. Its isoform3, DIA2C, together with CSK are sequentially activated by GTPase RhoD to regulate the motility of early endosomes through interactions with the actin cytoskeleton [PMID: 12577064].

GO terms

Biological Process

GO:0007015 actin filament organization
GO:0007292 female gamete generation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.