Family

Kynurenine 3-monooxygenase (IPR027545)

Short name: Kynurenine_monooxygenase

Family relationships

None.

Description

Kynurenine 3-monooxygenase (also known as kynurenine 3-hydroxylase) catalyses the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). It has a key role in tryptophan catabolism [PMID: 12974953] and is required for synthesis of quinolinic acid, a neurotoxic NMDA (N-methyl-D-aspartate) receptor antagonist.

The entry also identifies a protein from Drosophila willistoni (B4MPK3) which is a fusion of the kintoun and kynurenine 3-monooxygenase proteins.

GO terms

Biological Process

GO:0019805 quinolinate biosynthetic process
GO:0006569 tryptophan catabolic process

Molecular Function

GO:0004502 kynurenine 3-monooxygenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP