Very-long-chain 3-oxoacyl-CoA reductase, fungal (IPR027533)

Short name: 3_ketoreductase_fungal

Overlapping homologous superfamilies

Family relationships


Very-long-chain 3-oxoacyl-CoA reductase (EC: is a component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. It catalyses the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids [PMID: 11792704, PMID: 12087109, PMID: 12684876].

GO terms

Biological Process

GO:0030497 fatty acid elongation

Molecular Function

GO:0045703 ketoreductase activity

Cellular Component

GO:0005783 endoplasmic reticulum

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.