Enolase-phosphatase E1, eukaryotes (IPR027511)

Short name: ENOPH1_eukaryotes

Overlapping homologous superfamilies

Family relationships


This entry represents the enolase-phosphatase E1 (ENOPH1, also known as MASA) from eukaryotes. ENOPH1 is a bifunctional enzyme that promotes the conversion of 2,3-diketo-5-methylthio-1-phosphopentane to 1,2-dihydroxy-3-keto-5-methylthiopentene anion (an aci-reductone) in the methionine salvage pathway. Besides its function as a phosphatase, it possesses enolase activity that cannot be classified as typical enzymatic enolisation [PMID: 15843022]. It's structure has been resolved [PMID: 15843022].

This entry also matches a number of probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 enzymes from plants.

GO terms

Biological Process

GO:0019509 L-methionine salvage from methylthioadenosine

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.