1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, eukaryotes (IPR027496)

Short name: ARD_euk

Overlapping homologous superfamilies

Family relationships


1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (also known as MTCBP-1) (EC: is an eukaryotic enzyme that catalyses the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). It shows significant homology to the bacterial acireductone dioxygenase (ARD), which is an enzyme in the methionine salvage pathway (MTA cycle) [PMID: 15938715, PMID: 20195658]. MTCBP-1 is necessary for hepatitis C virus replication in an otherwise non-permissive cell line [PMID: 11602742]. MTCBP-1 interacts and inhibits the activity of membrane-type 1 matrix metalloproteinase (MT1-MMP/MMP-14) in promoting tumor cell migration and invasion [PMID: 20195658].

MTCBP-1 contains the cupin sequence motif and belongs to the Cupin superfamily composed of proteins with diverse functions [PMID: 20195658].

GO terms

Biological Process

GO:0019509 L-methionine salvage from methylthioadenosine

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.