Domain

HIV-1 Nef protein, core domain (IPR027481)

Short name: HIV-1_Nef_core

Domain relationships

None.

Description

Human immunodeficiency virus 1 (HIV-1) negative factor (Nef protein) accelerates virulent progression of acquired immunodeficiency syndrome (AIDS) by its interaction with specific cellular proteins involved in signal transduction and host cell activation. Nef has been shown to bind specifically to a subset of the Src family of kinases [PMID: 9351809].

Negative factor (Nef) has a two-domain structure consisting of an N-terminal anchor domain and a core domain separated by a specific cleavage site of the HIV proteases. The N-terminal domain is not compactly folded and constitutes a mobile membrane anchor and linker to the core domain [PMID: 8174561, PMID: 10339411].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
SUPERFAMILY