Domain

Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains (IPR027463)

Short name: AcrB_DN_DC_subdom

Domain relationships

None.

Description

The multidrug exporter AcrB is the inner membrane component of the AcrAB-TolC drug efflux system in Escherichia coli, responsible for the resistance of this organism to a wide range of drugs. AcrB exists as a homotrimer, with each subunit containing 12 transmembrane (TM) helices and a large periplasmic part formed by two loops between TM helices 1 and 2 and TM helices 7 and 8. The trimer consists of three prominent domains, the TM domain, the adjacent pore domain and the TolC docking domain [PMID: 17194213].

This entry represents two subdomains, known as DN and DC, found in the TolC docking domain of multidrug resistance proteins like AcrB [PMID: 21905116].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
SUPERFAMILY