Domain

Hypoxia-inducible factor 1-alpha inhibitor, domain II (IPR027452)

Short name: FIH-1_domII

Domain relationships

None.

Description

This entry represents the domain II of the hypoxia-inducible factor 1-alpha inhibitor, which is composed of a central beta-barrel surrounded by eight alpha-helices. It consists of two domains. Domain I runs from N terminus to residue 300 and is mainly composed of the central beta-barrel and six alpha-helices surrounding them. Domain II (residues 301-349) comprising two consecutive alpha-helices stretches away from domain I. Domain II, which is completely missing in all known structures of the dioxygenase family, forms strong interactions with the same region of the 2-fold symmetry related molecule [PMID: 12482756, PMID: 12432100, PMID: 12446723].

Hypoxia-inducible factor 1-alpha inhibitor hydroxylates a specific Asn residue in the C-terminal transactivation domain (CAD) of HIF-1 alpha. The hydroxylation prevents interaction of HIF-1 with transcriptional coactivators. It also hydroxylates specific Asn, Asp and His residues within ankyrin repeat domain-containing proteins [PMID: 12080085, PMID: 12042299, PMID: 17003112].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D