Homologous Superfamily

MAP kinase activated protein kinase, C-terminal (IPR027442)

Short name: MAPKAPK_C


This superfamily represent the C-terminal domain of the MAP kinase activated protein kinases (MAPKAPKs). Proteins containing this domain include Mapkapk2, Mapkapk3 and Mapkapk5. Mapkapk2 and Mapkapk3 are mainly involved in post-transcriptional regulation of gene expression and play an role in inflammation and cancer [PMID: 20599781]. Mapkapk5 is a regulator of mTORC1 signaling and is invovled in post-transcriptional regulation [PMID: 21336308, PMID: 9480836].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.