Homologous Superfamily

Lipoxygenase, domain 3 (IPR027433)

Short name: Lipoxygenase_dom_3


This superfamily represents a subdomain found in lipoxygenases. This superfamily is part of the C-terminal domain superfamily described by IPR036226.

Lipoxygenases (EC:1.13.11.-) are a class of iron-containing dioxygenases which catalyses the hydroperoxidation of lipids, containing a cis,cis-1,4-pentadiene structure. They are common in plants where they may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. In mammals a number of lipoxygenases isozymes are involved in the metabolism of prostaglandins and leukotrienes [PMID: 3017195]. Sequence data is available for the following lipoxygenases:

  • Plant lipoxygenases (EC: Plants express a variety of cytosolic isozymes as well as what seems to be a chloroplast isozyme [PMID: 7508918].
  • Mammalian arachidonate 5-lipoxygenase (EC:
  • Mammalian arachidonate 12-lipoxygenase (EC:
  • Mammalian erythroid cell-specific 15-lipoxygenase (EC:

The iron atom in lipoxygenases is bound by four ligands, three of which are histidine residues [PMID: 8502991]. Six histidines are conserved in all lipoxygenase sequences, five of them are found clustered in a stretch of 40 amino acids. This region contains two of the three iron-ligands; the other histidines have been shown [PMID: 1567851] to be important for the activity of lipoxygenases.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.