Homologous Superfamily

Myosin IQ motif-containing domain superfamily (IPR027401)

Short name: Myosin_IQ_contain_sf

Overlapping entries


This superfamily represents a subdomain that spans the IQ motif (IPR000048) of myosins.

The IQ motif is an extremely basic unit of about 23 amino acids, whose conserved core usually fits the consensus A-x(3)-I-Q-x(2)-F-R-x(4)-K-K. The IQ motif, which can be present in one or more copies, serves as a binding site for different EF-hand proteins including the essential and regulatory myosin light chains, calmodulin (CaM), and CaM-like proteins [PMID: 1558751, PMID: 9141499]. Many IQ motifs are protein kinase C (PKC) phosphorylation sites [PMID: 1824695, PMID: 8424932]. Resolution of the 3D structure of scallop myosin has shown that the IQ motif forms a basic amphipathic helix [PMID: 8127365].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.