Homologous Superfamily

Coronovirus spike glycoprotein, heptad repeat 2 domain (IPR027400)

Short name: S_HR2

Overlapping entries


Coronovirus enter target cells through fusion of viral and cellular membranes mediated by the viral envelope glycoprotein S. Trimers of Coronovirus S glycoprotein constitute the typical viral spikes. The precursor S protein is processed by host cell furin or furin-like protease to yield the mature S1 and S2 proteins [PMID: 2984314].

This superfamily represents one of the two heptad repeat domains found in the S protein which involves in helix-helix interfaces [PMID: 15604146, PMID: 15123674, PMID: 17176042, PMID: 16507566].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.