Homologous Superfamily

DNA topoisomerase I, C-terminal (IPR027362)

Short name: TopoI_C

Overlapping entries


Type I topoisomerases (type IB isomerases) relax positive and negative supercoils and are very important in DNA replication. The C-terminal segment of this enzyme constitutes the catalytic domain. The catalytic domain contains five amino acids, conserved in all eukaryotic type IB topoisomerases. Its structure consists of ten alpha helices and a three-strand beta sheet, and resembles the catalytic domains of site-specific recombinases that act via a topoisomerase IB-like mechanism [PMID: 9529259].

This entry represents the carboxyl lobe of the catalytic domain (domain 2), and consists of four alpha-helices (helices 6-10).

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.