NPH3 domain (IPR027356)

Short name: NPH3_dom

Overlapping homologous superfamilies


Domain relationships



The NRL (for NPH3/RPT2-Like) family is formed by signaling molecules specific to higher plants. Several regions of sequence and predicted structural conservation define members of the NRL family, with three domains being most notable: an N-terminal BTB domain, a centrally located NPH3 domain, and a C-terminal coiled coil domain. The function of the NPH3 domain is not yet known [PMID: 10542152, PMID: 10662859, PMID: 15031408, PMID: 15598797, PMID: 17493935, PMID: 20031912, PMID: 19357428, PMID: 21990941].

Some proteins known to contain a NPH3 domain include:

  • Arabidopsis non-phototropic hypocotyl 3 (NPH3), may function as an adapter or scaffold protein in plants.
  • Arabidopsis root-phototropisme 2 (RPT2), a signal transducer involved in phototropic response and stomatal opening in association with phototropin 1 (phot1).
  • Oriza coleoptile phototropism 1 (CPT1), the rice ortholog of NPH3. It is required for phototropism of coleoptiles and lateral translocation of auxin.

This entry represents the NPH3 domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles