Pathways & interactions
Coronin 1C (IPR027333)
Short name: CORO1C
Overlapping homologous superfamilies
- WD40/YVTN repeat-like-containing domain superfamily (IPR015943)
- WD40-repeat-containing domain superfamily (IPR036322)
- Coronin (IPR015505)
- Coronin 1C (IPR027333)
Coronins belongs to the WD40-repeat family, which contains the WD40 motifs that act as the protein-protein interaction sites. There are several isoforms of Coronin in mammalian cells [PMID: 10461187].
This entry represents Coronin 1C (also knowns Coronin 3). Coronin 1C contains two actin-binding sites that bind to actin filaments [PMID: 22364218]. It may be involved in cytokinesis, motility, and signal transduction. Expression of Coronin 1C has been linked to tumour malignancy in hepatocellular carcinoma (HCC) and glioblastoma cells [PMID: 23292607, PMID: 18189330].
- PTHR10856:SF10 (PTHR10856:SF10)