Domain

TPX2 central domain (IPR027330)

Short name: TPX2_central_dom

Domain relationships

None.

Description

This entry represents the central domain found in the eukaryotic targeting protein for Xklp2 (TPX2) protein. TPX2 is a microtubule-associated protein that targets a plus end-directed motor (Xklp2) to the minus ends of microtubules in the mitotic spindle. This domain is close to the C-terminal of TPX2. The protein importin alpha regulates the activity of TPX2 by binding to the nuclear localisation signal in this domain [PMID: 12727873].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam