TPX2, C-terminal (IPR027329)

Short name: TPX2_C

Overlapping homologous superfamilies


Domain relationships



This entry represents a conserved region approximately 60 residues long within the eukaryotic targeting protein for Xklp2 (TPX2). Xklp2 is a kinesin-like protein localised on centrosomes throughout the cell cycle and on spindle pole microtubules during metaphase. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenance of spindle bi-polarity [PMID: 8548825, PMID: 10871281]. TPX2 is a microtubule-associated protein that mediates the binding of the C-terminal domain of Xklp2 to microtubules. It is phosphorylated during mitosis in a microtubule-dependent way [PMID: 10871281].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.