Microtubule associated protein MAP2/MAP4/Tau (IPR027324)

Short name: MAP2/MAP4/Tau

Family relationships


Proteins in this family contains a microtubule binding domain that is found in MAP2, MAP4, Tau, and their homologues. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (IPR001084), and a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport [PMID: 15642108, PMID: 11576531].

MAP2 may stabilise the microtubules against depolymerisation [PMID: 3205744, PMID: 3142041].

MAP4 is a non-neuronal microtubule-associated protein that promotes microtubule assembly [PMID: 12773533, PMID: 10791892].

Tau promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity [PMID: 21985311]. Hyperphosphorylated forms of TAU has been linked to Alzheimer disease [PMID: 2484340].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008017 microtubule binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.