Family

Microtubule-associated protein 4 (IPR027323)

Short name: MAP4

Family relationships

Description

Microtubule-associated protein 4 (MAP4) is a non-neuronal microtubule-associated protein that promotes microtubule assembly [PMID: 12773533, PMID: 10791892]. It contains a microtubule binding domain (Tau/MAP repeats) that shares homology with neuronal microtubule-associated protein MAP2 and Tau [PMID: 1905296]. It is a ubiquitous heat-stable MAP responsible for stabilisation of microtubules [PMID: 15840946]. Overexpression of MAP4 causes a shift of tubulin dimers to a polymerised fraction and formed dense, stable microtubule networks [PMID: 12855424]. The persistent transcriptional up-regulation of MAP4, cardiac alpha- and beta-tubulinis is linked to the cytoskeletal abnormality during severe pressure overload-induced cardiac hypertrophy [PMID: 20436166].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008017 microtubule binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER