Family

Microtubule-associated protein 1B (IPR027321)

Short name: MAP1B

Family relationships

Description

MAP1-family proteins are microtubule-associated proteins (MAPs) that bind along the microtubule lattice. Mammalian genomes usually contain three family members, MAP1A, MAP1B and MAP1S. Only one family member, Futsch, is found in Drosophila.

Human MAP1A and MAP1B, are predominantly expressed in neurons, where they are thought to be important in the formation and development of axons and dendrites [PMID: 16938900, PMID: 21984824]. Human MAP1A and MAP1B stabilise microtubules and interact with other cellular components, including filamentous actin and signalling proteins. The activity of MAP1A and MAP1B is controlled by upstream signalling mechanisms, including the MAP kinase and glycogen synthase kinase-3 beta pathways [PMID: 16938900].

This entry represent MAP1B. It may bind to at least two tubulin subunits in the polymer. This bridging of subunits might be involved in nucleating microtubule polymerisation and in stabilising microtubules [PMID: 18075266]. Besides its microtubule regulation functions, MAP1B also acts as a signalling protein involved in normal physiology and pathological conditions in the nervous system [PMID: 24700609].

GO terms

Biological Process

GO:0000226 microtubule cytoskeleton organization
GO:0007399 nervous system development

Molecular Function

GO:0008017 microtubule binding

Cellular Component

GO:0005874 microtubule

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER